Published Journal Articles

Displaying 1 - 10 of 23
E.g., 26 Sep 2017
E.g., 26 Sep 2017
12 Aug 2015



Glycated haemoglobin A1c (HbA1c) measurement is recommended as an alternative to fasting plasma glucose (FPG) for the diagnosis of pre-diabetes and type 2 diabetes. However, evidence suggests discordance between HbA1c and FPG. In this study we examine a range of metabolic risk features, pro-inflammatory cytokines, acute-phase response proteins, coagulation factors and white blood cell counts to determine which assay more accurately identifies individuals at i...

22 Jul 2015


Mean corpuscular volume (MCV) is a measure of the average volume of red blood cells. The detection of an elevated MCV, termed macrocytosis (with or without anemia), often prompts an extensive and costly work-up for an underlying cause and/or referral to secondary care. Known determinants of macrocytosis listed in textbooks include vitamin B12 and folate deficiency, alcohol use (with or without associated liver disease), hemolysis, hypothyroidism, coeliac disease, drug use, and hemato...

4 Jun 2015

Background: The prevalence of type 2 diabetes within the Republic of Ireland is poorly defined, although a recent report suggested 135,000 cases in adults aged 45+, with approximately one-third of these undiagnosed. This study aims to assess the prevalence of undiagnosed and diagnosed diabetes in middle-aged adults, and compare features related to either condition, in order to investigate why certain individuals remain undetected.

Methods: This was a cross-sectional study involving a s...

4 Jun 2015



Despite recommendations that central obesity assessment should be employed as a marker of cardiometabolic health, no consensus exists regarding measurement protocol. This study examined a range of anthropometric variables and their relationships with cardiometabolic features and type 2 diabetes in order to ascertain whether measurement site influences discriminatory accuracy. In particular, we compared waist circumference (WC) measured at two sites: (1) immed...

30 Apr 2015

Hypertension is the most common modifiable risk factor for cardiovascular disease (CVD) and contributes to more than nine million deaths annually.1,2 Favourable secular trends in population blood pressure (BP) levels have been reported in many developed countries.2 In Ireland, favourable trends in population BP levels have contributed to 28% reduction in coronary heart disease deaths over the past two decades.3 In a modelling study, we have demonstrated that improving specific food choices (i...

21 Apr 2015

Background. To effectively meet the health care needs of multimorbid patients, the most important psychosocial factors associated with multimorbidity must be discerned. Our aim was to examine the association between self-reported adverse childhood experiences (ACEs) and multimorbidity and the contribution of other social, behavioural and psychological factors to this relationship.


We analysed cross-sectional data from the Mitchelstown study, a population-based cohort re...

19 Mar 2015


Blood pressure variability (BPV) has been associated with cardiovascular events; however, the prognostic significance of short-term BPV remains uncertain. As uncertainty also remains as to which measure of variability most accurately describes short-term BPV, this study explores different indices and investigates their relationship with subclinical target organ damage (TOD). We used data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47-73 years (n=2...

5 Jan 2015



There is little research on overall cardiovascular (CV) health among couples. Our aim was to examine concordance levels for CV health among couples, using the American Heart Association ideal health metrics, and to investigate if the CV health of an individual is associated with that of his or her partner.


There is a positive association between the overall cardiovascular health of an individual and that of his/her partner.


17 Dec 2014



Data-driven approaches to dietary patterns are under-utilized; latent class analyses (LCA) are particularly rare. The present study used an LCA to identify subgroups of people with similar dietary patterns, explore changes in dietary patterns over a 10-year period and relate these dynamics to sociodemographic factors and health outcomes.


The 1998 baseline and 2008 follow-up of the Cork and Kerry Diabetes and Heart Disease Study. Diets we...

11 Dec 2014


Electronic health records (EHR)support clinical management, administration, quality assurance, research, and service planning. The aim of this study was to evaluate a clinical data management programme to improve consistency, completeness and accuracy of EHR information in a large primary care centre with 10 General Practitioners (GPs). A Clinical Data Manager was appointed to implement a Data Management Strategy which involved coding consultations using ICPC-2 coding, tailore...